Virus Infection and mRNA Nuclear Export

Gene expression in eukaryotes begins with transcription the nucleus, followed by synthesis of messenger RNA (mRNA), which is then exported to cytoplasm for its translation into proteins. Along and translation, mRNA export through nuclear pore complex (NPC) an essential regulatory step eukaryotic gene expression. Multiple factors regulate hence Interestingly, proteins from certain types viruses interact these infected cells, such interaction interferes host cell favor viral export. Thus, hijack mechanism, leading a reduction downregulation immune/antiviral responses. On other hand, mRNAs successfully evade surveillance system are efficiently nucleus enables continuation virus life cycle. Here, we present this review summarize mechanisms suppress during infection, as well key strategies that use facilitate their These studies have revealed new potential antivirals may be used inhibit transport enhance export, thereby promoting immune